We are proud to announce the publication of 2 major articles involving our GeCo service for the analysis and interpretation of genomic data
The first study (Lehmann-Che et al., Nature Communications), conducted in collaboration with Professor Hugues de Thé, describes the identification of different mechanisms of resistance to treatment in acute promyelocytic leukaemias by exome analysis of primary tumor couples -rechute in 23 patients. These results, extremely important at the fundamental and clinical levels, demonstrate that retinoic acid alone does not eliminate all pre-leukemic cells.
Lehmann-Che J, Bally C, Letouzé E, et al. Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia. Nat Commun. 2018 May 24;9:2047. doi: 10.1038/s41467-018-04384-5.
“GeCo has been absolutely critical in advancing our projects. We had the chance to work with a competent, responsive team, perfectly understanding our questions and responding quickly with solutions à la carte. I have only one regret, not to have known them sooner! “
Pr. Hugues de Thé, Professeur au Collège de France,
Chef service Biochimie Hôpital Saint-Louis,
Directeur de recherche INSERM
The second study (Debiec et al., JASN), carried out in collaboration with Professor Pierre Ronco, describes the identification of polymorphisms of the HLA locus involved in the predisposition to nephrotic syndrome, via a multi-ethnic association study. This innovative statistical approach, hailed in a newspaper editorial, allowed .us to dissect the potentially causal SNPs within the locus.
Debiec H, Dossier C, Letouzé E, et al. Transethnic, Genome-Wide Analysis Reveals Immune-Related Risk Alleles and Phenotypic Correlates in Pediatric Steroid-Sensitive Nephrotic Syndrome. J Am Soc Nephrol. 2018 Jun 14. pii: ASN.2017111185. doi: 10.1681/ASN.2017111185.
“The GeCo service provided us with fast and accurate biostatistical analyses in our research program on nephrotic syndrome predisposition genes. These analyzes enabled us, through a trans-ethnic association (GWAS) study, to identify alleles at the HLA-D locus significantly associated with the development of the disease and to establish major correlations between the genotype and phenotype of the patients. These analyzes were made very rapidly using data from NGS and SNP chips.”
Prof. Pierre Ronco, Membre de l’Académie de Médecine
Chef de Service Néphrologie et Dialyse, Hôpital Tenon, AP-HP
Directeur de Recherche INSERM